Stem Cells of Human Hair Follicles Can Differentiate Into Neurons: Region-Specific Multipotency of Human Hair Follicle Stem Cells
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چکیده
Hair follicle stem cells in the hair follicle bulge area of mice are nestinand CD34-positive, and keratin 15 (K15)negative. The mouse hair follicle stem cells are multipotent and can differentiate into neurons, glial cells, keratinocytes, smooth muscle cells, and melanocytes (Proc. Natl. Acad. Sci. USA 102, 5530-5534, 2005). Recently, pluripotent stem cells have been identified in human hair follicles (Am. J. Path. 168, 1879-1888, 2006). The stem cells in hair follicles of human scalp express nestin and embryonic-stem-cell transcription factors Nanog and Oct4. The human hair follicle stem cells also can differentiate into neurons, smooth muscle cells, and melanocytes.
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